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Expected Research Outputs of WG3

1. To identify at least the 2 most important co-morbidities to consider when designing preclinical and clinical cardioprotection studies (factors include age, male sex, diabetes, hypertension, hypercholesterolemia).

2. To identify at least the 2 most important co-medications to consider when designing preclinical and clinical cardioprotection studies (co-medications include anti-platelet agents, statins, anesthetics, nitrates).

Working Group 4: Consortium

Many of the cardioprotective therapies that have failed in the clinical setting did not show consistent and robust cardioprotection in the experimental setting. This can be attributed to methodological limitations of the pre-clinical studies including lack of randomization, non-blinded treatment allocation, non-blinded data analysis, lack of standardized animal models and IRI protocols, and the lack of rigor in statistical methods. Therefore, more rigorous testing of novel cardioprotective therapies in the experimental setting is required to ensure that only the most promising therapies are investigated in the clinical arena. As such in this COST Action proposal, we will put in place a Consortium for (a) multi-center experimental testing of new cardioprotective therapies in clinically relevant small/large animal and human models of acute IRI; and (b) testing of new cardioprotective therapies in proof-of-concept clinical studies in patients subjected to acute IRI including STEMI and CABG patients.

The Consortium, which will be termed the European Cardioprotection Consortium (ECC), will allow multi-site testing of novel cardioprotective therapies in clinically relevant experimental small and large animal models and is, in part, modeled on the National Institute of Health-sponsored CAESAR collaborative network (Consortium for Preclinical Assessment of Cardioprotective Therapies) in the United States( Schwartz-Longacre et al., 2011 ; 2018 New 4 Kaws Black BlackClearGlow Basketball Shoes For Men Authentic Sneakers 2018 Limited Release 4147 store 2015 online zFR4A
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). The ECC will improve upon the NIH CAESAR collaborative network by (a) building on the infrastructure and knowledge obtained from the 3 WGs, in identifying novel cardioprotective targets and innovative strategies; and (b) undertaking proof-of-concept clinical studies in STEMI and CABG patients.

Expected Research Outputs of WG4

1. To put in place a network of research centers across Europe that will constitute the ECC for multi-center randomized controlled pre-clinical and clinical testing of novel cardioprotective therapies.

2. To standardize acute myocardial IRI protocols across the consortium and select which small animal (mouse, rat, rabbit) and large animal (pig, dog) AMI/HF models to include in the ECC.

3. To identify at least 4 novel cardioprotective therapies from WG 1, 2, 3 and key confounders highlighted in WG3 for testing in our ECC.

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According to Elon Musk

What’s late? What’s ahead of schedule? Tracking Musk’s goals for Tesla, SpaceX, and everything else he dreams up.

By Tom Randall

Updated Feb 01, 2018

Click To Enter

02/13/2057
Other | Full Transition to Electric Vehicles
07/15/2037
Tesla | No More Steering Wheels
02/13/2037
Other | 12% to 15% of Human Workforce Unemployed by Automation
05/25/2032
SpaceX | Humans Depart for Mars
12/31/2027
SpaceX | Crewed Launch of the Mars Ship (ITS)
07/15/2027
Tesla | Half of U.S. Vehicles Will Be Electric
07/15/2027
Tesla | All U.S. Cars Will Be Autonomous
04/20/2027
Neuralink | Brain Interfaces for Healthy People
02/13/2027
Other | Almost All New Cars Are Fully Autonomous
02/11/2025
Tesla | Tesla Valued at $700 Billion
01/31/2024
SpaceX | Space Internet—Mesh Network Complete
12/31/2022
SpaceX | Interplanetary Transport System's Maiden Voyage
06/06/2022
Tesla | Electric Planes Become Compelling
04/20/2021
Neuralink | First Improvements to the Human Brain
12/31/2020
Tesla | 500,000 Cars a Year
12/31/2020
Tesla | Gigafactory Reaches Full Production
12/31/2020
Tesla | Model S Gets 1,200 km (746 miles) Under Ideal Conditions
12/31/2020
Tesla | Next Gen Roadster Launch
12/31/2020
Tesla | 1 Million Cars a Year
10/10/2020
Tesla | Autonomous Cars Are Capable of Letting Drivers Sleep
12/31/2019
Tesla | Model Y Launch
12/31/2019
Tesla | Solar Gigafactory Produces 1 GW Annually
06/06/2019
Tesla | Tesla Semi Scale Production
04/13/2019
Tesla | Pickup Truck Unveiling
01/31/2019
SpaceX | Space Internet—Launch Campaign Starts
12/31/2018
SpaceX | First Space Tourists
12/31/2018
SpaceX | Moon Mission
12/31/2018
SpaceX | Refly a Rocket Within 24 Hours
12/31/2018
SpaceX | First Mission to Mars
12/31/2018
SpaceX | Red Dragon to Mars
12/31/2018
Tesla | A Tripling of Superchargers—to 18,000
12/31/2018
Tesla | Model 3 Production of 10,000 a week
10/28/2018
Boring | First Major Transit Route (15+ Miles)
07/11/2018
Tesla | Add 100 New Service Centers
06/30/2018
Tesla | Solar Roof Tile in Tuscan/Slate
03/31/2018
SpaceX | Space Internet—Second Prototype
03/31/2018
SpaceX | Fly with a Used Nose Cone
03/31/2018
Tesla | Model 3 Production of 2,500 a week
02/28/2018
Boring | First 2 Mile Tunnel
12/31/2017
SpaceX | Space Internet—First Prototype
12/31/2017
SpaceX | Recover a Rocket's Nose Cone
12/31/2017
Tesla | Gigafactory Starts Production
12/31/2017
Tesla | Model 3 Launch
12/31/2017
Tesla | Model S Gets 1,000 km (621 miles) Under Ideal Conditions
12/31/2017
Tesla | World's Largest Grid Battery in Australia
12/31/2017
Tesla | Hands-Free Trip Across America
12/31/2017
Tesla | Tesla Network
12/31/2017
Tesla | Two to Four New Gigafactories Announced
12/31/2017
Tesla | Add 350 Mobile Service Vans and 1,400 Technicians
12/31/2017
Tesla | Supercharger Network Across Canada
12/31/2017
Tesla | First 100,000 Model 3s
12/31/2017
Tesla | Model 3 All-Wheel Drive
12/31/2017
Tesla | Model 3 Production of 5,000 a week
12/21/2017
Tesla | White Interior Option for the Model 3
11/30/2017
Tesla | $35,000 Base Configuration of the Model 3
10/31/2017
Tesla | Model 3 Sales to Customers Who Aren't Employees
09/30/2017
Tesla | First 70 Tesla Solar Stores
09/29/2017
SpaceX | Update to the Mars Plan
09/22/2017
Tesla | Solar Roof Installations
09/22/2017
Tesla | Solar Gigafactory Opening
07/23/2017
Tesla | First "Full Self-Driving" Features
07/09/2017
Boring | Car Elevator Prototype for the Electric Sled
07/07/2017
Tesla | First Model 3 Produced
07/02/2017
Tesla | Model 3 Release Date Announcement
06/23/2017
SpaceX | Falcon 9 Block 5 (Final Version)
05/03/2017
Tesla | Mini Bus Unveiling
05/03/2017
Tesla | Semi Unveiling
04/30/2017
Boring | Boring Machine Starts to Dig
04/30/2017
Tesla | Solar Roof Orders
02/25/2017
Boring | Boring Company Breaks Ground
01/31/2017
Tesla | Powerwall 2 Installations
12/31/2016
SpaceX | Reusable Rocket Returns to Space
12/31/2016
SpaceX | Crew Dragon Test Launch
12/31/2016
Tesla | Battery Deployment for California Grid
12/31/2016
Tesla | New Autopilot Reaches Parity With Old
03/31/2016
Tesla | Model 3 Unveiling
12/31/2015
SpaceX | Sexy Spacesuits
09/21/2015
Tesla | Powerwall Installations
12/31/2014
SpaceX | Unveil Crew Dragon Capsule
12/31/2014
SpaceX | Human Space Flight
10/09/2014
Tesla | First Dual Motor All-Wheel Drive
07/01/2014
SpaceX | Land a Rocket Booster on Earth
04/30/2014
SpaceX | Emergency Launch Abort: In-Flight Test
12/31/2013
SpaceX | Emergency Launch Abort: Pad Test
12/31/2013
SpaceX | Falcon Heavy Launch
12/31/2013
Tesla | Model X Launch
12/31/2012
SpaceX | Falcon 9 Launch to GTO
12/31/2011
Tesla | Model S Launch
09/30/2009
SpaceX | Dragon Docks with Space Station
06/30/2008
SpaceX | Dragon Returns From Orbit
12/31/2007
SpaceX | Falcon 9 Launch
07/01/2007
Tesla | Roadster Launch
12/31/2005
SpaceX | Falcon 5
03/31/2004
SpaceX | Falcon 1 Launch

The Future According to Elon Musk presents three distinct views.

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Volume 27, Issue 4 , p805–815.e4, 3 April 2018
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2017
Order Now

Sun of Justic: Byzantine Chant for Christmas in Greek, Arabic, and English

OPEN FOR PRE-ORDERS! SHIPS ON RELEASE DAY DECEMBER 8, 2017

Cappella Romana Media combines passion with scholarship in its exploration of early and contemporary music of the Christian East and West.

A Holiday Record Unlike Any Other Disc 1: Traditional Chants in Greek and Arabic Disc 2: Traditional Chants in English

A Holiday Record Unlike Any Other

Featuring classical chants in Greek primarily by Petros Peloponnesios (1730–1778). Adaptations into Arabic primarily by Mitri El Murr (1880–1969) and those into English by John Michael Boyer (b. 1978) closely echo the originals in form, style, and grace.

This debut release by PRÓTO presents traditional chants for the Byzantine celebration of Christmas, including selections from The Royal Hours, Vespers, Matins, and the Divine Liturgy. A deluxe 32-page booklet is included with full texts in Greek, Arabic, and English.

PRÓTO is a collaboration of two protopsaltes (“first cantors”): John Michael Boyer, Protopsaltis of the Greek Orthodox Metropolis of San Francisco; and the Reverend Deacon John Rassem El Massih, Protopsaltis of the Antiochian Orthodox Christian Archdiocese of North America. Their shared vision is excellence in traditional Byzantine Music as well as the advancement, development, and composition of traditional Byzantine Music in the English language.

20
Jan
2015

Good Friday in Jerusalem

Medieval Byzantine Chant from the Church of the Holy Sepulchre

Coming February 10, 2015! HELP US CHART THE RECORD by pre-ordering!

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Produced since 2004 by GRAMMY Award-winning producer Steve Barnett, Cappella Romana performs “music of purity and radiance” () in concerts of “luminous beauty” (). Appearances in New York, Chicago, Los Angeles, London, Athens, Utrecht, Regensburg, and in the US Northwest all demonstrate how Cappella Romana “continues its ascent” (). With , Cappella Romana’s intrepid male ensemble features international cantors from Greece, the UK, and the US, with Stelios Kontakiotis from Tinos, Greece, as principal soloist. Together they perform these chants with captivating modal inflections that underscore the deep pathos and personal drama of Good Friday. These profound selections for the 8th- and 9th-century ceremonies invoke an elaborate stational liturgy in Jerusalem’s most sacred Christian sites. Recorded in the splendid Stanford Memorial Church and sung in Byzantine Greek. Extensive scholarly article by founding artistic director Dr. Alexander Lingas (City University London, University of Oxford), with full texts in Greek and translations in English. Pre-Order on Amazon!

14
Jan
2015

Stock of our February CD is now in hand! Street date for this release is February 10, but you can pre-order on Amazon NOW !

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Cappella Romana’s latest release is in conjunction with our Good Friday in Jerusalem Concert Series in Seattle and Portland, February 6-8! Hear Medieval Byzantine chant, the fraternal repertoire to Latin chant in the West, composed for 8th and 9th-century celebrations of Holy Week in Jerusalem’s Church of the Holy Sepulchre. Hymns from the seventh to the ninth centuries by Jerusalem’s great church fathers—Patriarch Sophronios, Kosmas the Melodist, and Saint John Damascene—include the famous Orthodox hymn “Semeron krematai” (“Today He who is hung upon the tree”) sung to its original medieval melody.

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Good Friday in Jerusalem
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